Over the past few decades there have been numerous publications on the pharmacokinetic (PK) and pharmacodynamic (PD) models of drugs used in anaesthetic practice. These models can predict a drug’s distribution, elimination and clinical effect.
An important use of these models is within target controlled infusion (TCI) systems where the optimal administration of a drug to achieve rapid and stable plasma and effect site concentrations are predicted. The goals of these system are to quickly achieve a clinical effect whilst limiting the side effects of the medication.
To create and maintain a python module to simulate target controlled infusions.
Source Code: github.com/opentiva/opentiva
Example web app: opentiva.com
Full documentation: readthedocs
The first version of opentiva was released in May 2019. The python module simulates target controlled infusions for a variety of classes of drugs. Going forward there will be regular updates to the drug models available.
